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Soft tissue tumors classification

Soft tissue tumors classification

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Soft tissue tumors classification


  • De Schepper, Pieter Van Dyck, Dirk Van Dyck, Jan Gielen, Paul M. Parizel and Jan Sijbers (November 16th 2011). Learn about the risk factors for soft tissue Diagnosis. Order appropriate molecular tests for accurate diagnosis of soft tissue sarcomas. Better recognize and diagnose recently characterized soft tissue tumors. 1 The annual incidence of soft tissue sarcomas in companion animals is about 35 per 100,000 dogs at risk and 17 per 100,000 cats at risk. [] Adequate tissue should be obtained via either core-needle or incisional biopsy for microscopic examination, with a careful review by a pathologist who is experienced in diagnosing sarcomas. The fourth edition of the World Health Organization (WHO) Classification of Tumours of Soft Tissue and Bone was published in February 2013, and serves to provide an updated classification scheme In recent years, new tumor entities have been described and previously known tumor types have undergone a reassessment. AJR Am J Roentgenol. Novel uses of immunohistochemistry in the diagnosis and classification of soft tissue tumors. 5772/27757. Primary bone tumors are categorized according to their tissue of origin into cartilage, osteogenic, fibrogenic, fibrohistiocytic, haematopoietic, vas-cular, lipogenic tumors and several other tumors, like Ewing sarcoma and giant cell tumor [1]. Following are the most common soft tissue sarcoma types, as well as their tissues of origin: Jaber Juntu, Arthur M. Prior to the 1970s, surgery was the primary therapy for malignant soft tissue tumors, and most patients with high-grade tumors had a poor prognosis and a significant mortality. Get this from a library! WHO classification of tumours of soft tissue and bone. This new classification includes several changes: newly included sections (gastrointestinal stromal tumors…), newly recognized entities (pseudomiogenic haemangioendothelioma, haemosiderotic fibrolipomatous tumour…), and new genetic and molecular data Soft tissue tumor 1. Thy are also classified as either benign, malignant or semi-malignant, as well as tumor-like lesions [2]. soft tissue tumours (known as soft tissue sarcomas) have significant risk of distant metastasis, ranging in most instances from 20% to almost 100%, depending upon histological type and grade. Folpe is the author of over 170 medical publications, principally in the areas of soft tissue pathology and diagnostic immunohistochemistry, the co-author of the 6th edition of Although imaging reviews on soft tissue tumors already regarded nerve sheath tumors previously as typical soft tissue tumors [18], nerve sheath tumors have been included for the first time in the WHO classification of soft tissue tumors since 2013 (Table 11. Histopathological Classification of Childhood Soft Tissue Sarcoma. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable Start studying Soft Tissue Tumors + bone tumors. A simplified classification of myxoid soft-tissue tumors Benign soft tissue tumors such as fibromas,lipomas,myx-omas, or schwannomas may be confused with malignant soft tissue tumors and, in some cases, may lead to either excessive treatment for benign lesions or inadequate treat-ment for malignant ones. Soft tissue tumors include a heterogeneous group of diagnostic entities, most of them benign in nature and behavior. Available from: Jaber Juntu Soft tissue tumors belong to a group of neoplasms that can cause particular problems in their diagnosis and/or treatment. Each volume is prepared by a group of internationally recognized experts. This protocol is NOT required for accreditation purposes for the following: Procedure Biopsy (includes core needle biopsy, incisional biopsy, or excisional biopsy) Due to the high incidence of lipomas, angiolipomas, and liposarcomas, adipocytic tumors represent the largest single group of mesenchymal tumors. malignancy. It aims to serve both as a systematic, descriptive textbook and as a rich pictorial database of soft tissue masses. Children between 10 and 14 years old These are further divided into blastomas, hematopoietic tumors, soft tissue, bones, neural tissue tumors and othes. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies SOFT TISSUE TUMORS. Classification Benign soft tissue tumours Rubin BP, Fletcher CD, Inwards C, et al. Some can be quite aggressive. The WHO 2002 classification of soft tissue tumors is as follows: This, however, has been revised under the 2013 WHO tissue tumor classification system 4. • The numerous advances in the genetic/molecular features of soft tissue and bone tumors has facilitated more accurate classification and the development of useful diagnostic tools. Pediatric soft tissue sarcomas are a heterogenous group of malignant tumors that originate from primitive mesenchymal tissue and account for 7% of all childhood tumors (rhabdomyosarcomas, 4%; other soft tissue sarcomas, 3%). Tumors of soft tissue are more common than bone tumors. Earn Lifelong Learning and SAM credits. The revised 2013 World Health Organization (WHO) classification of soft-tissue sarcomas introduced several important changes. 2 In dogs, sarcomas have been Most soft tissue and bone tumors can be classified according to differentiation as determined by morphologic, immunohistochemical, and genetic features. FLETCHER Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States Summary The fourth edition of the World Health Organization (WHO) Classiï¬ cation of Tumours of Soft The true incidence of soft tissue tumors is nearly impossible to determine, especially for benign tumors, because many of these tumors are not biopsied. World Health Organization (WHO) Classification of Soft Tissue Sarcomas. Giant cell tumour of tendon sheath: 9252 / 0 Diffuse-type giant cell tumour: 9251 / 0 Deep benign fibrous histiocytoma: 8830 / 0 Intermediate (rarely metastasizing) Plexiform fibrohistiocytic tumour: 8835 / 1 Giant cell tumour of soft tissues The new World Health Organization (WHO) classification of soft tissue tumours was published in 2013, 11years after the previous edition. • Soft tissue is defined as complex of nonepithelial extra skeletal structure of body exclusive of supportive tissue of various organs and the hematopoietic/ lymphoid tissue. Please try again later. soft tissue tumors classification. It brings with it some fundamental as well as minor changes to the previous edition. who classification of tumours of soft tissue and bone Download who classification of tumours of soft tissue and bone or read online books in PDF, EPUB, Tuebl, and Mobi Format. Identify the cause (etiology; pathogenesis), cell or tissue of origin, and frequency (prevalence rate) 2. With the advent of the new format for WHO tumor classifications, there have been major changes in each of the most recent volumes (2002 and 2013) concerning soft tissue neoplasms. Tumor behavior is classified as benign, intermediate (locally aggressive), intermediate (rarely metastasizing), and ma-lignant. Soft Tissue Tumors Imaging • MR cannot reliably distinguish benign from malignant soft tissue masses • Non Specific: • Contrast enhancement (solid v. The World Health Organization (WHO) has published a classification system for tumors of the soft tissue and bone, which includes detailed cytogenetic and molecular data. Some symptoms are uneven posture, pain in the trapezius muscle, and cervical inflexibility [difficulty in turning the head]. The TNM classification for soft tissue sarcoma is provided below. These are called intermediate soft tissue tumors. Lymph node involvement is not characteristic of most sarcomas except rhabdomyosarcoma and synovial, clear cell, vascular, and epithelioid sarcomas. A wide-ranging review of soft tissue pathology focused on identifying and understanding common and rare tumors found within soft tissue. soft tissue tumors classification Atypical lipomatous tumor/well-differentiated liposarcoma Benign soft-tissue tumors are fairly common and are treated with surgery alone. [citation needed] The most common site to which soft-tissue sarcoma spreads is the lungs. They can occur almost anywhere: within and between muscles, ligaments, nerves and blood vessels. This succinct, yet meaningful, field guide deconstructs all presentations in one easy-to-read and comprehensive text. In our practice, a general approach to reaching a definitive diagnosis of soft tissue tumors is to first In 2013, the World Health Organization (WHO) published an updated classification of tumors of the soft tissue and bone. cystic, hematomas, necrosis for biopsy or trtmt This comprehensive review of soft tissue tumor pathology covers a broad range of practical topics useful for practicing pathologists and pathologists in training. Description: WHO Classification of Soft Tissue and Bone is the fifth volume of the 4th Edition of the WHO series on histological and genetic typing of human tumors. These are predominantly tumors of adults, but 15% arise in children and adolescents. Fletcher, K. This section introduces you to the first method: cancer classification based on histological type. Perhaps foremost has been the disappearance of "malignant fibrous histiocytoma" and "hemangiopericytoma. [citation needed] The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary David N. Because of this the diagnosis of soft tissue sarcoma may be unsuspected at the time of presentation and an inappropriate biopsy performed. The series is currently in its fifth edition. Click Download or Read Online button to get who classification of tumours of soft tissue and bone book now. Perhaps the most widely used currently is that system proposed by the World Health Organization in 2004, which classifies salivary neoplasms as primary or secondary, benign or malignant, and also by tissue of origin. [Christopher D M Fletcher;] -- WHO Classification of Soft Tissue and Bone is the fifth volume of the 4th Edition of the WHO series on histological and genetic typing of human tumours. 3. JO AND CHRISTOPHER D. Many benign tumors are found in soft tissues. ( Hisham) This feature is not available right now. However, there is a diverse range of benign soft tissue tumours that may mimic soft tissue sarcomas and collectively these tumours are relatively common. Cancer Classification. . Their morphological appearance is kaleidoscopic and varies. This site is like a library, Use search box in the widget to Novel uses of immunohistochemistry in the diagnosis and classification of soft tissue tumors. This third, revised and updated edition includes new chapters on genetics and molecular biology and on pathology of soft tissue tumors, with respect to the new World Health Organization (WHO) classification of soft tissue tumors. Utilize immunohistochemistry for accurate diagnosis of soft tissue tumors. Soft-tissue sarcomas commonly originate in the upper body, in the shoulder or upper chest. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable Biologic Behavior of Soft Tissue Tumors in the WHO Classification System. *FREE* shipping on qualifying offers. Soft tissue sarcomas compared with carcinomas and other neoplasms, constitute fewer than 1% of all cancers. It includes an approach to differential diagnosis based on dominant histologic patterns (spindle cell, epithelioid, pleomorphic, round cell, Molecular classification of soft tissue sarcomas and its clinical applications Shilpa Jain1, Ruliang Xu1, Victor G. " classification of tumors of soft tissue arranges these tumors into 12 groups according to their histogenesis. Adipocytic tumors Benign lipoma 8850/0* lipomatosis 8850/0 lipomatosis of nerve 8850/0 Soft tissue sarcomas (STS) constitute a heterogeneous category of soft tissue neoplasia composed mostly of uncommon tumors of diverse histology, different biology and varied outcomes. WHO classification (2002) of fibrohistiocytic tumors of soft tissue (deep) and ICD-0 codes: Benign. Hornick MD, PhD, in Practical Soft Tissue Pathology: a Diagnostic Approach (Second Edition), 2019 Tumor Classification. Bone Tumors: Soft Tissue Tumors: Soft Tissue Tumor Types: Soft Tissue Tumor General Information: Soft Tissue Tumor Classification: Online Orthopedic Oncology & Pathology Course: Childhood Sarcomas: Diagnosis and Treatments: Questions and Answers: Case Studies: Lectures & Presentations: Textbook(s) Video Presentations: Resources The classification of soft tissue tumors continues to evolve, following the description of “new” tumor types, the discovery of novel molecular genetic alterations, and the development of increasingly specific diagnostic immunohistochemical markers. 1 x 1 Kransdorf, M. Describe the evolution of diagnostic immunohistochemistry for soft tissue tumors. Start studying SOFT TISSUE TUMORS. These tumors can't spread to other parts of the body. There are many types of soft tissue tumors, and not all of them are cancerous. Authoritative and Concise Update on Classification of Skin Tumors Including Diagnostic Criteria, Pathological Features, Prognosis and Associated Genetics Provided by Book Editors and Contributors. The word benign means they're not cancer. Soft Tissue Tumors of Intermediate Malignancy of Uncertain Type 33. The numerous advances in the genetic/molecular features of soft tissue and bone tumors has facilitated more accurate classification and the development of useful diagnostic tools. Children less than 4 years old b. Classification of Soft Tissue Tumors by Machine Learning Algorithms, Soft Tissue Tumors, Fethi Derbel, IntechOpen, DOI: 10. Extensive pelvic surgeries, either for oncologic reasons or following trauma, are highly demanding because of the irregular and Soft tissue sarcomas are a heterogeneous population of mesenchymal tumors that comprise 15% and 7% of all skin and subcutaneous tumors in the dog and cat, respectively. The current 2013 World Health Organization (WHO) Classification of Tumors of Soft Tissue and Bone 1 was published 11 years after the prior volume. BONE AND SOFT TISSUE TUMORS Fabrizio Remotti MD DEFINITION zSoft tissue pathology deals with tumors of the connective tissuesconnective tissues. In 2013, the World Health Organization (WHO) published an updated classification of tumors of the soft tissue and bone. zThe concept of soft tissue is understood broadly to include non-osseous tumors of extremities, trunk wall, retroperitoneum and mediastinum and head &mediastinum, and head & neck. In addition to their classification on the basis of tissue type, as described above, soft tissue tumors are further subdivided according to their biologic behavior into benign tumors, intermediate tumors (those having malignant potential), and malignant tumors. This book is a product of collaboration of 159 authors from 24 different countries throughout the world. sification of soft tissue tumors and describes the imaging characteristics of several types of soft tis-sue tumors of the head and neck. Here's your ideal reference on the diagnosis of tumors of the skeletal muscles, connective tissue, fat, and related structures. 1 The histologic categories of neoplasms include epithelial lesions, soft tissue tumors, tumors of bone and cartilage, hematolymphoid tumors, neuroectodermal tumors, germ cells tumors and secondary Overview of Pelvic Resections: Surgical Considerations and Classification Jacob Bickels and Martin Malawer OVERVIEW The bony pelvis and its enveloping soft tissues are a common site for bone and soft-tissue tumors. Don\u2019t skim the surface of diagnosis; gain in-depth, full-color insight with Cutaneous Soft Tissue Tumors. No other source matches Enzinger and Weiss's scope and depth of coverage in thi Apply a pattern-based approach to the differential diagnosis of soft tissue tumors. The final pathology came back as a high grade soft tissue sarcoma. Malignant Soft Tissue Masses • Teo et al • 22 peripheral hemangiomas and 22 primary malignant soft tissue masses (MFH, rhabdomyosarcoma, neurofibrosarcoma, primitive neuroectodermal tumors, 6 others) • T1-weighted imaging –No reliable distinguishing feature • T2-weighted imaging The new World Health Organization (WHO) classification of soft tissue tumours was published in early 2013, almost 11 years after the previous edition. If the tumor grows or causes pain, it should be assessed by a doctor. Some soft tissue tumors behave in ways between a cancer and a non-cancer. This new publication was published 11 years after the last publication dealing with this topic and provides updates predominantly based on the identification of new genetic findings in different tumors types. Cancers are classified in two ways: by the type of tissue in which the cancer originates (histological type) and by primary site, or the location in the body where the cancer first developed. WHO Classification of Soft Tissue and Bone is the fifth volume of the 4th Edition of the WHO series on histological and genetic typing of human tumors. Malignant entities, soft tissue sarcomas, are rare tumors that account for1% of all malignancies. The WHO classification persists to consider atypical lipoma (atypical lipomatous tumor) and well-differentiated liposarcoma as essentially synonymous (Table 11. Some (but not all) histologically low grade sarcomas have a metastatic risk of only 2-10%, but such lesions may advance in grade in a Pathology and Genetics of Tumours of Soft Tissue and Bone (IARC WHO Classification of Tumours) [The International Agency for Research on Cancer, C. Primary bone tumors are rare compared to metastases (secondary bone tumors) and hematologic conditions which include plasmocytomas and malignant lymphomas (). Soft tissue tumor Dr NARMADA PRASAD TIWARI 2. com. zExcluded (with a few exceptions) are organ specific tumors WHO Classification of Soft Tissue and Bone is the fifth volume of the 4th Edition of the WHO series on histological and genetic typing of human tumours. • 5% of all soft tissue sarcomas • Not very common (many tumors formerly classified as fibrosarcoma, have been redefined as another entity because og special immunohistochemical stains) • Can affect all ages, but more common between third and fifth decade. Wiestler 9 · Paul Kleihues10 · David W. Ellison11 Explore the latest in soft-tissue tumors, including recent advances in classification, diagnosis, and medical and surgical management. Louis1 · Arie Perry2 · Guido Reifenberger3,4 · Andreas von Deimling4,5 · Dominique Figarella‑Branger6 · Webster K. Features that can help narrow the differential diagnosis of a soft tissue mass in the neck are discussed in detail. Because they are relatively rare, the individual physician usually has For instance, a very recent, magisterial review on the role of cytogenetics and molecular diagnostics in soft tissue pathology noted that of the well over 100 lesions in the Fourth Edition of the World Health Organization (WHO) Classification of Tumors of Soft Tissue and Bone, published in 2013 [1], nearly half show recurrent genetic Common pediatric malignant tumors may be classified according to age of the child: a. This new publication was published 11 years after the last publication dealing with this topic and provides updates predominantly based on the identification of new genetic Distribution of Soft Tissue Sarcoma by Age and Histology. More appropriately utilize modern diagnostic techniques in soft tissue tumors. 2 During that period, many changes have taken place in soft tissue and bone tumor classification, predominantly based on the identification of new genetic findings in different tumor types. If you have a soft tissue sarcoma or are close to someone who does, knowing what to expect can help you cope. The WHO lists the following cell types in its classification of soft tissue sarcomas:[1 ,2 ] Adipocytic tumors. D. Arch Pathol Lab Med 2006; 130:1616. Substantial developments in immunohistochemistry (IHC), cytogenetics and molecular genetics of STS have caused a WHO classification of tumours of soft tissue TNM classification of soft tissue sarcomas 1 Tumours of soft tissue: Introduction Epidemiology Etiology Clinical features Imaging of tumours of soft tissue Grading and staging of sarcomas 2 Adipocytic tumours Lipoma Lipomatosis Lipomatosis of nerve Lipoblastoma Angiolipoma Myolipoma of soft tissue Soft tissue tumors may be classified into tumors of adipose tissue, tumor and tumor like lesions of fibrous tissue, fibrohistiocytic tumors, tumors of skeletal muscles, tumors of smooth muscles, vascular tumors, peripheral nerve tumors and tumors of unknown histiogenesis. WHO Classification of Soft Tissue and Bone is the fifth volume of the 4th Edition of the WHO series on histological and genetic typing of human tumours. Better understand and apply the modern WHO classification of soft tissue tumors and understand why it evloves. M. Here you can find out all about soft tissue sarcomas in adults, including risk factors, symptoms, how they're found, and how they're treated. Soft Tissue Hemangioma vs. Prieto2, Peng Lee1,3,4,5 Department of 1Pathology, 3Urology and 4Cancer Institute, New York University School of Medicine, 5New York Harbor Soft tissue tumor 1. Soft tissue tumors have traditionally been classified according to line of differentiation—that is, which normal cell type the neoplastic cells most closely resemble. These tumors vary widely in how they look and behave. The various types of soft tissue sarcomas are generally named for the type of connective tissue in which they form. The World Health Organization (WHO) classification system divides SN tumors into categories based tissue of origin and benignity vs. Benign soft-tissue tumors in a large referral population: distribution of specific diagnoses by age, sex, and location. 2,8-15 The relative infrequency and Diagnosis, Classification, and Management of Soft Tissue Sarcomas Due to the diverse nature of salivary gland tumours, many different terms and classification systems have been used. No other textbook matches its scope and depth of coverage in this complex and challenging area of surgical pathology, and no other text contains as much practical information on differential diagnosis. Soft tissue tumors (STT) represent a complex group of lesions that may show a broad range of differentiation. Malignant Soft Tissue Tumors of Uncertain Type Dr. Mertens] on Amazon. This article offers an overview of recent developments in the classification and interpretation of soft tissue tumors. zThe concept of soft tissue is understood broadly to include non-osseous tumors of extremities, trunk wall, retroperitoneum and mediastinum, and head & neck. Cavenee7 · Hiroko Ohgaki8 · Otmar D. Organization (WHO) classification of tumors of soft tissue and bone published in 2013 up-dated the older 2002 classification, introduced several changes in soft-tissue tumor classifi-cation, and described new genetic and molec-ular data for the tumors [5, 6]. Selective review of publications from 1990 until 2008 from BONE AND SOFT TISSUE TUMORS Fabrizio Remotti MD DEFINITION zSoft tissue pathology deals with tumors of the connective tissues. The WHO (World Health Organization) classification has been up-to-dated in 2013 The latest edition of the WHO Classification of Tumours of Soft Tissue and Bone is a comprehensive, yet concise reference book. Describe the typical clinical appearance Jason L. Intermediate (locally aggressive). SOFT TISSUE TUMOR DR MANOJ DAS Ortho resident Institute Of Medicine , TUTH , Nepal 2. The WHO Classification of Tumours series are authoritative and concise reference books for the histological and molecular classification of tumours. If your primary viewing mode will be on a computer or tablet, we recommend the Online Video package. While the number of newly recognized entities included for the first time is fewer than that in 2002, there have instead been substantial steps forward in molecular genetic and cytogenetic WHO classification of soft tissue tumours: an update based on the 2013 (4th) edition VICKIE Y. They are the most common angiomatous lesions and represent up to 7% of all benign soft-tissue tumors 2. 10). The treating surgeon operated completely within the sartorius compartment and did not violate any other compartments, however the final pathology showed positive margins. Enzinger and Weiss's Soft Tissue Tumors is your essential medical reference on the diagnosis of tumors of the skeletal muscles, connective tissue, fat, and related structures. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome. However, as researchers have learned more about these rare tumors, many of these names have changed over time. zExcluded (with a few 32. PDF | Soft tissue tumors (STT) represent a complex group of lesions that may show a broad range of differentiation. [] Soft tissue sarcomas Includes soft tissue tumors of intermediate (locally aggressive and rarely metastasizing) potential and malignant soft tissue tumors. More easily avoid common pitfalls which may lead to misdiagnosis of soft tissue tumors. Children between 5 to 9 years old c. Biologic Behavior of Soft Tissue Tumors in the WHO Classification System The Evolving Classification of Soft Tissue Tumors. The more the tumor has invaded nearby tissues, the harder it is to completely remove. The WHO (World Health Organization) classification has been up-to-dated in 2013 for the purpose of uniformity. 2) and considered locally aggressive Soft Tissue Tumors Basic objectives for individual lesions identification and characteristics 1. Benign soft tissue tumors may or may not cause pain and vary widely in appearance. []Histology and grade are critical components of staging. Abstract. 3 Tumors and Tumorlike Lesions of the Skeleton and Soft Tissues General Considerations in Diagnosing Skeletal Tumors. WHO/IARC Classification of Tumours - WHO Blue Books. The classification of soft tissue tumors continues to evolve, following the description of “new” tumor types, the discovery of novel molecular genetic alterations, and the development of increasingly specific diagnostic immunohistochemical markers. The classification of soft tissue and bone tumors continues to evolve, following the description of "new" tumor types, the discovery of novel molecular genetic alterations, and the development of increasingly specific diagnostic immunohistochemical markers; these changes are included in the new World Health Organization (WHO) Classification of Soft tissue venous malformations, commonly known as soft tissue hemangiomas, are a location-dependent benign vascular soft tissue tumor. 30/11/2018 WHO Classification of Tumours of the Eye WHO Classification of Tumours, 4th Edition, Volume 12 Edited by Grossniklaus HE, Eberhart CG, Kivelä TT The WHO Classification of Tumours of the Eye is the 12th and final volume in the 4th edition of the WHO series on the classification of human tumours. J. What are my treatment options? Depending on the type of tumor you have, your doctor may or may not recommend surgery. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Protocol for the examination of specimens from patients with soft tissue tumors of intermediate malignant potential, malignant soft tissue tumors, and benign/locally aggressive and malignant bone tumors. List the predilection GAL – Gender predilection – Age predilection – Location predilection 3. INTRODUCTION. Most soft tissue and bone tumors can be classified according to differentiation as deter-mined by morphologic, immunohistochemical, and genetic features. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical Soft-tissue sarcomas are a diverse group of malignancies, and our rapidly improving understanding of their molecular pathogenesis and treatment is leading to better clinical outcomes. Krishnan Unni, F. Intoduction • Neoplastic condition arising from extra-skeletal mesoderm -Fibrous tissue -Smooth muscle -Skeletal muscle -Adipose tissue -Blood and lymphatics vessels -Peripheral nerves Soft tissue masses in children include the more common reactive and benign soft tissue masses but also include the rare and much more serious soft tissue sarcomas (STS). Soft tissue sarcomas may be heterogeneous, with more than 100 different entities described in the World Health Organization 2013 classification
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